Research Journal of Pharmaceutical Dosage Form and Technology

K. Sonu Sharma ¹, Rashmi Sharma ², G. Vidya Sagar ³

Affiliations
1 Suresh Gyan Vihar University, Jaipur, Rajasthan, IN
2 Mahatama Jyoti Rao Phule University, Jaipur, Rajasthan, IN
3 Veerayatan institute of Pharmacy, Bhuj, Kutch, Gujarat, IN

Abstract

Tablet swallowing difficulty primarily affects the geriatric and pediatric populations whereas unpalatable taste of drugs leads to patient noncompliance. To reduce these problems, a new dosage form known as Fast-Dissolving Tablet (FDT), is a tablet that dissolves or disintrigrants in the oral cavity without the need of water or chewing. It has been developed for oral administration, also called as fast-melt, rapimelts, porous tablets ,or fast disintegrating or orally disintegrating tablets (ODTs). In April 2007, the FDA issued a draft guidance, Guidance for Industry: Orally Disintegrating Tablets. Fast dissolving tablets can be prepared by various conventional methods like direct compression, wet granulation, moulding, spray drying, freeze drying, Cotton Candy Process and sublimation. In 1986, the first lyophilized fast-dissolving technology Zydis® was introduced (By Cardinal formerly R. P. Scherer) after that there was a continuous growth in names by different companies, now a number of fast-dissolving formulations are in market and the technology is still improving. Present review focuses on the need of FDTs, their advantages and comparative evaluation of latest technologies.

Keywords

Fast Dissolving Tablet, Orasolv, Durasolv, Patents.

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S. M. Sarode ¹, G. Vidya Sagar ², M. K. Kale ³, P. K. Nimase ⁴, A. P. Kulkarni ³, S. D. Firke ³, B. M. Firke ³, P. D. Warke ³, M. A. Chaudhari ³

Affiliations
1 C/O M. B. Sarode, Shanti nagar, Plot no.6, Yawal Road, Bhusawal (M.S.), IN
2 Veerayatan Institute of Pharmacy, Bhuj, Gujrat, IN
3 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
4 Smt.S.S.Patil college of Pharmacy, Chopda (M.S.), IN

Abstract

The objective of this investigation was to develop an intra gastric floating drug delivery system of clarithromycin and also attempts were made to sustain the release of clarithromycin. Multiple-unit floating beads of clarithromycin were prepared from sodium alginate solution containing Hydroxypropylmethylcellulose (K100M) and sunflower oil by using emulsion-gelation method. These beads were evaluated for entrapment efficiency, drug loading, buoyancy and in vitro drug release. All formulations were the floating lag time below two minutes and shows total floating duration more than ten hours. It was observed that entrapment efficiency, drug loading and buoyancy was greater with formulation containing two percent sodium alginate solution and five percent calcium chloride solution along with 500mg HPMC and five ml sunflower oil (i.e.F14) and also the result of in-vitro dissolution studies reveals that the formulation F14 gave sustained release pattern of clarithromycin upto 12 hrs.

Keywords

Floating Alginate Beads, Emulsion Gelation, Clarithromycin, Controlled Release.

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